| Round | Team | Opponent | H/A | Ground | Date |
| 1 |
 Sydney Swans
|
 West Coast Eagles
| A | Perth Stadium |
Sunday, 25 March 2018 at 7:20PM
|
| 2 |
Sydney Swans
|
 Port Adelaide Power
| H | SCG |
Sunday, 1 April 2018 at 4:40PM
|
| 3 |
Sydney Swans
|
 GWS Giants
| H | SCG |
Saturday, 7 April 2018 at 7:25PM
|
| 4 |
Sydney Swans
|
 Western Bulldogs
| A | Etihad Stadium |
Saturday, 14 April 2018 at 4:35PM
|
| 5 |
Sydney Swans
|
 Adelaide Crows
| H | SCG |
Friday, 20 April 2018 at 7:50PM
|
| 6 |
Sydney Swans
|
 Geelong Cats
| A | GMHBA Stadium |
Saturday, 28 April 2018 at 1:45PM
|
| 7 |
Sydney Swans
|
 North Melbourne Kangaroos
| H | SCG |
Saturday, 5 May 2018 at 7:25PM
|
| 8 |
Sydney Swans
|
 Hawthorn Hawks
| A | MCG |
Friday, 11 May 2018 at 7:50PM
|
| 9 |
Sydney Swans
|
 Fremantle Dockers
| H | SCG |
Saturday, 19 May 2018 at 7:25PM
|
| 10 |
Sydney Swans
|
 Brisbane Lions
| A | Gabba |
Saturday, 26 May 2018 at 4:35PM
|
| 11 |
Sydney Swans
|
 Carlton Blues
| H | SCG |
Friday, 1 June 2018 at 7:50PM
|
| 12 |
Sydney Swans
|
 St Kilda Saints
| A | Etihad Stadium |
Saturday, 9 June 2018 at 7:25PM
|
| 13 |
Sydney Swans
|
West Coast Eagles
| H | SCG |
Friday, 15 June 2018 at 7:50PM
|
| 15 |
Sydney Swans
|
 Richmond Tigers
| A | Etihad Stadium |
Thursday, 28 June 2018 at 7:20PM
|
| 16 |
Sydney Swans
|
Geelong Cats
| H | SCG |
Thursday, 5 July 2018 at 7:20PM
|
| 17 |
Sydney Swans
|
North Melbourne Kangaroos
| A | Etihad Stadium |
Sunday, 15 July 2018 at 3:20PM
|
| 18 |
Sydney Swans
|
 Gold Coast Suns
| H | SCG |
Saturday, 21 July 2018 at 2:10PM
|
| 19 |
Sydney Swans
|
 Essendon Bombers
| A | Etihad Stadium |
Friday, 27 July 2018 at 7:50PM
|
| 20 |
Sydney Swans
|
 Collingwood Magpies
| H | SCG |
Saturday, 4 August 2018 at 7:25PM
|
| 21 |
Sydney Swans
|
 Melbourne Demons
| A | MCG |
Sunday, 12 August 2018 at 3:20PM
|
| 22 |
Sydney Swans
|
GWS Giants
| A | Spotless Stadium |
Saturday, 18 August 2018 at 4:35PM
|
| 23 |
Sydney Swans
|
Hawthorn Hawks
| H | SCG |
Friday, 24 August 2018 at
|