| Round | Team | Opponent | H/A | Ground | Date |
| 1 |
 Western Bulldogs
|
 GWS Giants
| A | UNSW Canberra Oval |
Sunday, 25 March 2018 at 1:10PM
|
| 2 |
Western Bulldogs
|
 West Coast Eagles
| H | Etihad Stadium |
Sunday, 1 April 2018 at 3:20PM
|
| 3 |
Western Bulldogs
|
 Essendon Bombers
| H | Etihad Stadium |
Sunday, 8 April 2018 at 3:20PM
|
| 4 |
Western Bulldogs
|
 Sydney Swans
| H | Etihad Stadium |
Saturday, 14 April 2018 at 4:35PM
|
| 5 |
Western Bulldogs
|
 Fremantle Dockers
| A | Perth Stadium |
Saturday, 21 April 2018 at 8:10PM
|
| 6 |
Western Bulldogs
|
 Carlton Blues
| H | Etihad Stadium |
Friday, 27 April 2018 at 7:50PM
|
| 7 |
Western Bulldogs
|
 Gold Coast Suns
| H | Mars Stadium |
Saturday, 5 May 2018 at 1:45PM
|
| 8 |
Western Bulldogs
|
 Brisbane Lions
| H | Etihad Stadium |
Saturday, 12 May 2018 at 7:25PM
|
| 9 |
Western Bulldogs
|
 Adelaide Crows
| A | Adelaide Oval |
Friday, 18 May 2018 at 7:50PM
|
| 10 |
Western Bulldogs
|
 Collingwood Magpies
| A | Etihad Stadium |
Friday, 25 May 2018 at 7:50PM
|
| 11 |
Western Bulldogs
|
 Melbourne Demons
| H | Etihad Stadium |
Saturday, 2 June 2018 at 1:45PM
|
| 13 |
Western Bulldogs
|
 Port Adelaide Power
| A | Adelaide Oval |
Thursday, 14 June 2018 at 7:50PM
|
| 14 |
Western Bulldogs
|
 North Melbourne Kangaroos
| H | Etihad Stadium |
Saturday, 23 June 2018 at 7:25PM
|
| 15 |
Western Bulldogs
|
 Geelong Cats
| H | Etihad Stadium |
Friday, 29 June 2018 at 7:50PM
|
| 16 |
Western Bulldogs
|
 Hawthorn Hawks
| H | Etihad Stadium |
Saturday, 7 July 2018 at 7:25PM
|
| 17 |
Western Bulldogs
|
Melbourne Demons
| A | MCG |
Saturday, 14 July 2018 at 4:35PM
|
| 18 |
Western Bulldogs
|
West Coast Eagles
| A | Perth Stadium |
Sunday, 22 July 2018 at 3:20PM
|
| 19 |
Western Bulldogs
|
Port Adelaide Power
| H | Mars Stadium |
Sunday, 29 July 2018 at 3:20PM
|
| 20 |
Western Bulldogs
|
 St Kilda Saints
| A | Etihad Stadium |
Saturday, 4 August 2018 at 7:25PM
|
| 21 |
Western Bulldogs
|
North Melbourne Kangaroos
| A | Etihad Stadium |
Sunday, 12 August 2018 at 1:10PM
|
| 22 |
Western Bulldogs
|
Carlton Blues
| A | Etihad Stadium |
Sunday, 19 August 2018 at 1:10PM
|
| 23 |
Western Bulldogs
|
 Richmond Tigers
| A | MCG |
Friday, 24 August 2018 at
|